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KMID : 0357520220450060553
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Journal of Radiological Science and Technology
2022 Volume.45 No. 6 p.553 ~ p.560
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Clinical Risk Evaluation Using Dose Verification Program of Brachytherapy for Cervical Cancer
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Kang Dong-Jin
Shin Young?Joo
Kang Jin-Kyu
Jung Jae-Yong
Lee Woo-Jin
Baek Tae-Seong
Lee Bo-Ram
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Abstract
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The purpose of this study is to evaluate the clinical risk according to the applicator heterogeneity, mislocation, and tissue heterogeneity correction through a dose verification program during brachytherapy of cervical cancer. We performed image processing with MATLAB on images acquired with CT simulator. The source was modeled and stochiometric calibration and Monte-Carlo algorithm were applied based on dwell time and location to calculate the dose, and the secondary cancer risk was evaluated in the dose verification program. The result calculated by correcting for applicator and tissue heterogeneity showed a maximum dose of about 25% higher. In the bladder, the difference in excess absolute risk according to the heterogeneity correction was not significant. In the rectum, the difference in excess absolute risk was lower than that calculated by correcting applicator and tissue heterogeneity compared to the water-based calculation. In the femur, the water-based calculation result was the lowest, and the result calculated by correcting the applicator and tissue heterogeneity was 10% higher. A maximum of 14% dose difference occurred when the applicator mislocation was 20 mm in the Z-axis. In a future study, it is expected that a system that can independently verify the treatment plan can be developed by automating the interface between the treatment planning system and the dose verification program.
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KEYWORD
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Monte-Carlo algorithm, Dose verification Program, Applicator, Excess absolute risk, Secondary cancer risk
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